Estradiol is an essential female hormone which regulates various functions imperative to females. It is a steroid hormone which is synthesized from cholesterol, it the strongest estrogens which are produced naturally. The chief function of this hormone causes the maturation and maintenance of the female reproductive system. A natural increase in the level of Estradiol during the menstrual cycle leads to maturation and release of the egg and the thickening of uterine lining so that implantation can occur. Estradiol also promotes the formation of breast tissue and supplements in bone and cartilage thickness. Estradiol is produced by the ovaries in Premenopausal women. Estradiol levels are high at the time of ovulation and lowest at menstruation, the level of this hormone declines with age, with a huge decline at menopause as the ovaries switch off in this condition.
How Is Estradiol Produced?
Production of Estradiol is a result of reactions occurring in hypothalamic-pituitary-gonadal axis. The process starts in the hypothalamus; there is a release of a hormone called gonadotropin-releasing hormone which leads to the release of two more hormones from the pituitary known as luteinizing hormone and follicle stimulating hormone. These two hormones start the stimulation of the ovaries and immature follicles which starts the production of Estradiol. There is a communication established between Estradiol in the blood and the brain, this controls ovulation, development of the egg and menstrual cycle.
What Happens If Estradiol Level Declines?
Estradiol is an essential component in females and its decline may lead to various issues, one such issue is with bone development, women with low Estradiol are more prone to problems such as inadequate bone growth and osteoporosis. Girls with low content may find problems at puberty such as delayed or inadequate breast development, irregular menstrual cycle, and infertility. Estradiol has an important role to play in the brain as well, its low concentration can lead to depression, fatigue, and mood swings. A postmenopausal woman can experience various issues such as hot flushes, night sweats, dry vagina and mood swings, long-term absence of this hormone can cause osteoporosis.
Progynon Depot is a profusely used therapy for the treatment of menopausal symptoms in postmenopausal women, the most common symptoms are vaginal itching, hot flashes, burning, or dryness. Progynon Depot is a very effective therapy also called as hormonal replacement therapy, it is used as a substitute to naturally occurring estrogen creation by the ovaries which are now in insufficient amount either due to menopause or surgical removal of the ovaries. This drug is also used for the prevention and management of Osteoporosis and increased risk of fracture. In men, it can be used for the treatment of prostate cancer.
Progynon Depot contains as its key therapeutic component, a hormone called Estradiol valerate which is the synthetic analog of naturally occurring Estradiol. It is a female estrogen hormone which elicits a remedial response by replacing natural estrogens in a woman who can no longer produce enough estrogen.
Progynon Depot is available as a parenteral formulation in 10mg/ ml strength. For postmenopausal symptoms, the most used dose is 10 to 20 mg of Progynon Depot administered intramuscularly for every four weeks. The most used dose for management of prostate cancer is 30mg of Progynon Depot is for every 1 to 2 weeks.
A few notable adverse effects of this medication are nausea, bloating, vomiting, breast tenderness, weight changes, headache, stomach cramps, and thinning of scalp hair.
Points To Be Paid Heed Towards!
Go for regular physical tests and mammograms; also self-examine your breasts for lumps on a monthly basis. The use of this medication is contraindicated in people suffering from hepatic dysfunction, blood-clotting disorders, the recent history of heart attack or stroke, and hormone-dependent ovarian or thyroid cancer. There is a risk of developing breast cancer if you use this medication for longer than prescribed.
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